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This non-therapeutic biosimilar uses Cetuximab’s variable regions, ideal for research. It reacts with human EGFR (ErbB-1, a 170 kDa cell-surface receptor in the ErbB family). EGFR activates via binding ligands (EGF, TGFα, Amphiregulin, HB-EGF), turning from inactive monomer to active homodimer and triggering downstream cascades (MAPK, Akt, JNK) for DNA synthesis and cell proliferation. EGFR overexpression/constitutive activation links to many cancers; Cetuximab inhibits tumor proliferation by blocking EGF-EGFR interaction.
| Product Name | BioSIM anti-Human EGFR Antibody (Cetuximab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG1-kappa |
| Target | EGFR |
| Other Names | FabC225, IMC-225, cetuximab-IR700, CAS: 205923-56-4 |
| CAS | 205923-56-4 |
| Reactivity | Human |
| Host Species | Chimeric |
| Background | This non-therapeutic biosimilar uses Cetuximab’s variable regions, ideal for research. It reacts with human EGFR (ErbB-1, a 170 kDa cell-surface receptor in the ErbB family). EGFR activates via binding ligands (EGF, TGFα, Amphiregulin, HB-EGF), turning from inactive monomer to active homodimer and triggering downstream cascades (MAPK, Akt, JNK) for DNA synthesis and cell proliferation. EGFR overexpression/constitutive activation links to many cancers; Cetuximab inhibits tumor proliferation by blocking EGF-EGFR interaction. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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