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BiosimilarsInvestigate biological therapeutic mechanisms with cost-effective, research-grade biosimilar antibodies.
This non-therapeutic biosimilar shares variable regions with therapeutic Varlilumab (a human IgG1 mAb targeting CD27, a TNFR superfamily member). CD27 is on naive/memory T cells, Tregs, NK cells, and some B cells; its binding to CD70 boosts T cell functions. Varlilumab, an agonist, signals T cells, depletes CD27⁺ Tregs, and aids anti-tumor immunity (tested with anti-PD-1). This biosimilar suits in vitro/in vivo studies of CD27 signaling, T cell costimulation, etc.
| Product Name | BioSIM anti-Human TNFRSF7/CD27 Antibody (Varlilumab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG1-kappa |
| Target | TNFRSF7/CD27 |
| Other Names | 1F5, CDX-1127, CAS: 1393344-72-3 |
| CAS | 1393344-72-3 |
| Reactivity | Human |
| Host Species | Human |
| Background | This non-therapeutic biosimilar shares variable regions with therapeutic Varlilumab (a human IgG1 mAb targeting CD27, a TNFR superfamily member). CD27 is on naive/memory T cells, Tregs, NK cells, and some B cells; its binding to CD70 boosts T cell functions. Varlilumab, an agonist, signals T cells, depletes CD27⁺ Tregs, and aids anti-tumor immunity (tested with anti-PD-1). This biosimilar suits in vitro/in vivo studies of CD27 signaling, T cell costimulation, etc. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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