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This biosimilar antibody shares the same variable regions as therapeutic Canakinumab (a fully human IgG1 mAb), ideal for research. Canakinumab binds human IL-1β (a 17 kDa pro-inflammatory cytokine from monocytes, mediating inflammation and cellular activities like proliferation). IL-1 has IL-1α/β and two receptors (Type I signals, Type II is a decoy). It neutralizes IL-1β by blocking receptor interaction, not binding IL-1α or IL-1ra.
| Product Name | BioSIM anti-Human IL-1b Antibody (Canakinumab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | / |
| Target | IL-1b |
| Other Names | ACZ885, CAS: 914613-48-2 |
| CAS | 914613-48-2 |
| Reactivity | Human |
| Host Species | Human |
| Background | This biosimilar antibody shares the same variable regions as therapeutic Canakinumab (a fully human IgG1 mAb), ideal for research. Canakinumab binds human IL-1β (a 17 kDa pro-inflammatory cytokine from monocytes, mediating inflammation and cellular activities like proliferation). IL-1 has IL-1α/β and two receptors (Type I signals, Type II is a decoy). It neutralizes IL-1β by blocking receptor interaction, not binding IL-1α or IL-1ra. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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