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NK-1.1 surface antigen, also known as CD161b/CD161c, is encoded by the NKR-P1B/NKR-P1C gene. It is expressed on NK cells and NK-T cells in some mouse strains. NK-1.1 has also been shown to play a role in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers.
| Catalog | IV0111 |
| Product Name | InVivoPro Anti-Mouse NK1.1(CD161) Antibody in vivo antibody, Clone PK136 |
| Size | 1mg/5mg/25mg/50mg/100mg |
| Isotype | Mouse IgG2a κ |
| Clone | PK136 |
| Target | NK1.1 |
| Other Names | CD161 antigen, CD161, CD161/NK1.1 |
| Isotype Control Catalog Code | Mouse IgG2a Isotype Control |
| Dilution Buffer | PBS, pH 7.2, contains no stabilizers or preservatives |
| Reactivity | Mouse |
| Host Species | Mouse |
| How much antibody to use in vivo | 200-500 μg per mouse; or 10-20 mg/kg. This range is based off the most recent publication data using the PK136 clone in vivo. Each investigator should determine their own optimal working dilution for specific applications. |
| Background | NK-1.1 surface antigen, also known as CD161b/CD161c, is encoded by the NKR-P1B/NKR-P1C gene. It is expressed on NK cells and NK-T cells in some mouse strains. NK-1.1 has also been shown to play a role in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers. |
| Applications | In vivo NK cell depletion, Flow cytometry |
| Purification | protein A or G |
| Storage | This antibody is stable for at least 2 months when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C or -80°C. Avoid repeated freeze thaw cycles. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS Buffer, PH 7.2, with no carrier protein, or preservatives. |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg, by the LAL method |
| Purity | 99% |
Yamano, Tomoyoshi et al. "Ex vivo-expanded DCs induce donor-specific central and peripheral tolerance and prolong the acceptance of donor skin grafts". Blood vol. 117,9 (2011): 2640-8.
Westerhuis, Geert et al. "Persisting NK cell alloreactivity in the presence of long-term stable hematopoietic chimerism". Experimental hematology vol. 37,6 (2009): 739-43.
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