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This non-therapeutic Siltuximab biosimilar, sharing the same variable regions as the therapeutic antibody, is ideal for research. It reacts with human IL-6 (21-28 kDa, expressed by T/B lymphocytes, monocytes, fibroblasts, endothelial cells). IL-6 signals via a type I receptor (IL-6Rα/CD126, gp130/CD130), influencing immune/inflammatory responses, neuronal development, and acute phase reactions. It blocks IL-6 binding to soluble and membrane-bound IL-6R.
| Product Name | BioSIM anti-Human IL-6 Antibody (Siltuximab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG1-kappa |
| Target | IL-6 |
| Other Names | CLLB8, CNTO328, CAS: 541502-14-1 |
| CAS | 541502-14-1 |
| Reactivity | Human |
| Host Species | Chimeric |
| Background | This non-therapeutic Siltuximab biosimilar, sharing the same variable regions as the therapeutic antibody, is ideal for research. It reacts with human IL-6 (21-28 kDa, expressed by T/B lymphocytes, monocytes, fibroblasts, endothelial cells). IL-6 signals via a type I receptor (IL-6Rα/CD126, gp130/CD130), influencing immune/inflammatory responses, neuronal development, and acute phase reactions. It blocks IL-6 binding to soluble and membrane-bound IL-6R. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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