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This non-therapeutic biosimilar antibody shares the same variable regions as therapeutic Labetuzumab, ideal for research. A humanized anti-carcinoembryonic antigen antibody, it binds CEACAM5 (aka CEA/CD66e) — expressed in fetal digestive system, overexpressed in cancers, acting as a CAM to inhibit anoikis and promote tumorigenesis/metastasis (upregulated in breast, colon, lung, NEPC, pancreatic cancers). It aids CEACAM5-targeted immunotherapy research; in vitro/in vivo studies show it inhibits CEACAM5+ tumor proliferation.
| Product Name | BioSIM anti-Human CEACAM5/CEA Antibody (Labetuzumab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG1-kappa |
| Target | CEACAM5/CEA |
| Other Names | hMN14, IMMU-130, hMN-14-SN-38, hMN-14-SN-38ADC, hMN14-CL-SN-38, LabetuzumabGovitecan, CAS: 219649-07-7 |
| CAS | 219649-07-7 |
| Reactivity | Human |
| Host Species | Humanized |
| Background | This non-therapeutic biosimilar antibody shares the same variable regions as therapeutic Labetuzumab, ideal for research. A humanized anti-carcinoembryonic antigen antibody, it binds CEACAM5 (aka CEA/CD66e) — expressed in fetal digestive system, overexpressed in cancers, acting as a CAM to inhibit anoikis and promote tumorigenesis/metastasis (upregulated in breast, colon, lung, NEPC, pancreatic cancers). It aids CEACAM5-targeted immunotherapy research; in vitro/in vivo studies show it inhibits CEACAM5+ tumor proliferation. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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