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This non-therapeutic biosimilar shares Teclistamab’s variable regions, ideal for research. Teclistamab, a humanized IgG4 bispecific mAb, targets BCMA (malignant plasma cells) and CD3ε (T cells), redirecting T cells to eliminate BCMA+ multiple myeloma via T-cell activation. Its Fc has S228P/L234A/L235A mutations to reduce immunological effects, valuable for studying T-cell engagement, bispecific mechanisms and BCMA-targeted therapies.
| Product Name | BioSIM anti-Human BCMA x CD3 Bispecific Antibody (Teclistamab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG4-lambda |
| Target | BCMA x CD3 |
| Other Names | Bispecific, BCMA, JNJ-64007957, JNJ-7957, Ab-957, CAS: 2119595-80-9 |
| CAS | 2119595-80-9 |
| Reactivity | Human |
| Host Species | Chimeric |
| Background | This non-therapeutic biosimilar shares Teclistamab’s variable regions, ideal for research. Teclistamab, a humanized IgG4 bispecific mAb, targets BCMA (malignant plasma cells) and CD3ε (T cells), redirecting T cells to eliminate BCMA+ multiple myeloma via T-cell activation. Its Fc has S228P/L234A/L235A mutations to reduce immunological effects, valuable for studying T-cell engagement, bispecific mechanisms and BCMA-targeted therapies. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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