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MHC class I antigens are heterodimers consisting of one alpha chain (44 kDa) associated with ß2 microglobulin (11 .5 kDa).The antigen is expressed by all nucleated cells at varying levels. MHC Class I molecules present endogenously synthesized antigenic peptides to CD8 T cells. Clone M1/42.3.9.8 recognizes a conserved epitope on the 44-46 kDa heavy chain of H-2 antigens in association with beta2-microglobulin that is expressed across the majority of mouse haplotypes.
| Catalog | IV0149 |
| Product Name | InVivoPro Anti-Mouse MHC Class I (H-2) in vivo antibody, Clone M1/42.3.9.8 |
| Size | 1mg/5mg/25mg/50mg/100mg |
| Isotype | Rat IgG2a κ |
| Clone | M1/42.3.9.8 |
| Target | MHC Class I (H-2) |
| Other Names | H-2 Class I, MHC Class I |
| Isotype Control Catalog Code | IV0105 or Rat IgG2a Isotype Control |
| Dilution Buffer | PBS, pH 7.2, contains no stabilizers or preservatives |
| Reactivity | Mouse |
| Host Species | Rat |
| How much antibody to use in vivo | Each investigator should determine their own optimal working dilution for specific applications. |
| Background | MHC class I antigens are heterodimers consisting of one alpha chain (44 kDa) associated with ß2 microglobulin (11 .5 kDa).The antigen is expressed by all nucleated cells at varying levels. MHC Class I molecules present endogenously synthesized antigenic peptides to CD8 T cells. Clone M1/42.3.9.8 recognizes a conserved epitope on the 44-46 kDa heavy chain of H-2 antigens in association with beta2-microglobulin that is expressed across the majority of mouse haplotypes. |
| Applications | Ex vivo blocking of MHC I-dependent interactions |
| Purification | protein A or G |
| Storage | This antibody is stable for at least 2 months when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C or -80°C. Avoid repeated freeze thaw cycles. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS Buffer, PH 7.2, with no carrier protein, or preservatives. |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg, by the LAL method |
| Purity | 99% |
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