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IL-10 is a 17-21 kDa cytokine which is primarily produced by monocytes and, to a lesser extent, Th2 cells, mast cells, Tregulatory cells, and certain subsets of activated T and B cells. IL-10 has pleiotropic effects in immunoregulation andinflammation. It down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules onmacrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-κB activity,and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggest that this cytokine isan essential immunoregulator in the intestinal tract. The JES5-2A5 antibody has been shown to neutralize the bioactivity ofIL-10
| Catalog | IV0155 |
| Product Name | InVivoPro Anti-Mouse IL-10 in vivo antibody, Clone JES5-2A5 |
| Size | 1mg/5mg/25mg/50mg/100mg |
| Isotype | Rat IgG1 κ |
| Clone | JES5-2A5 |
| Target | IL-10 |
| Other Names | CSIF, IL10A, MGC126450, MGC126451, TGIF |
| Isotype Control Catalog Code | Rat IgG1 Isotype Control |
| Dilution Buffer | PBS, pH 7.2, contains no stabilizers or preservatives |
| Reactivity | Mouse |
| Host Species | Rat |
| How much antibody to use in vivo | Each investigator should determine their own optimal working dilution for specific applications. |
| Background | IL-10 is a 17-21 kDa cytokine which is primarily produced by monocytes and, to a lesser extent, Th2 cells, mast cells, Tregulatory cells, and certain subsets of activated T and B cells. IL-10 has pleiotropic effects in immunoregulation andinflammation. It down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules onmacrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-κB activity,and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggest that this cytokine isan essential immunoregulator in the intestinal tract. The JES5-2A5 antibody has been shown to neutralize the bioactivity ofIL-10 |
| Applications | In vivo IL-10 neutralization, in vitro IL-10 neutralization |
| Purification | 0 |
| Storage | This antibody is stable for at least 2 months when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C or -80°C. Avoid repeated freeze thaw cycles. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS Buffer, PH 7.2, with no carrier protein, or preservatives. |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg, by the LAL method |
| Purity | 99% |
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