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NKG2D, a type II transmembrane lectin-like glycoprotein also known as CD314, is expressed on NK cells, NKT cells, CD8 T cells, γ/δ T cells, and macrophages. NKG2D has been implicated in anti-tumor surveillance, the immune response against viral infection, and in diabetes progression in NOD mice. The CX5 monoclonal antibody reacts with mouse NKG2D.
| Catalog | IV0176 |
| Product Name | InVivoPro Anti-Mouse NKG2D (CD314) in vivo antibody, Clone CX5 |
| Size | 1mg/5mg/25mg/50mg/100mg |
| Isotype | Rat IgG1 κ |
| Clone | CX5 |
| Target | NKG2D |
| Other Names | NKG2D, CD314, Klrk1 |
| Isotype Control Catalog Code | Rat IgG1 Isotype Control |
| Dilution Buffer | PBS, pH 7.2, contains no stabilizers or preservatives |
| Reactivity | Mouse |
| Host Species | Rat |
| How much antibody to use in vivo | Each investigator should determine their own optimal working dilution for specific applications. |
| Background | NKG2D, a type II transmembrane lectin-like glycoprotein also known as CD314, is expressed on NK cells, NKT cells, CD8 T cells, γ/δ T cells, and macrophages. NKG2D has been implicated in anti-tumor surveillance, the immune response against viral infection, and in diabetes progression in NOD mice. The CX5 monoclonal antibody reacts with mouse NKG2D. |
| Applications | In vivo NKG2D blockade, in vitro NKG2D blockade |
| Purification | protein A or G |
| Storage | This antibody is stable for at least 2 months when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C or -80°C. Avoid repeated freeze thaw cycles. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS Buffer, PH 7.2, with no carrier protein, or preservatives. |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg, by the LAL method |
| Purity | 99% |
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