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CD209b, also known as SIGN-R1, is a 37 kDa type II transmembrane C-type lectin receptor. CD209b is expressed on the surface of splenic marginal zone and lymph node medullary macrophages and is commonly used as a marker for these cells. The CD209b protein is involved in the innate immune response, it binds to and initiates uptake of various microorganisms by recognizing high-mannose-containing glycoproteins on their envelopes. The 22D1 monoclonal antibody reacts with mouse CD209b.
| Catalog | IV0174 |
| Product Name | InVivoPro Anti-Mouse CD209b(SIGN-R1) in vivo antibody, Clone 22D1 |
| Size | 1mg/5mg/25mg/50mg/100mg |
| Isotype | Armenian Hamster IgG |
| Clone | 22D1 |
| Target | CD209b |
| Other Names | CD209b,SIGN-R1 |
| Isotype Control Catalog Code | Armenian Hamster IgG Isotype Control |
| Dilution Buffer | PBS, pH 7.2, contains no stabilizers or preservatives |
| Reactivity | Mouse |
| Host Species | Armenian Hamster |
| How much antibody to use in vivo | Each investigator should determine their own optimal working dilution for specific applications. |
| Background | CD209b, also known as SIGN-R1, is a 37 kDa type II transmembrane C-type lectin receptor. CD209b is expressed on the surface of splenic marginal zone and lymph node medullary macrophages and is commonly used as a marker for these cells. The CD209b protein is involved in the innate immune response, it binds to and initiates uptake of various microorganisms by recognizing high-mannose-containing glycoproteins on their envelopes. The 22D1 monoclonal antibody reacts with mouse CD209b. |
| Applications | In vivo CD209b blockade |
| Purification | protein A or G |
| Storage | This antibody is stable for at least 2 months when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C or -80°C. Avoid repeated freeze thaw cycles. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS Buffer, PH 7.2, with no carrier protein, or preservatives. |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg, by the LAL method |
| Purity | 99% |
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